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[forebrain overgrowth] This spontaneous autosomal recessive mouse mutation is characterised by forebrain and facial defects, and spina bifida. The defects appear to result from excessive growth or cellular proliferation leading to abnormalities in neural tube closure (Harris et al, 1997). Honarpour et al (2001) have noted that the phenotype resembles that observed in APAF-1 knock-out mice. They have demonstrated that the gene affected is the APAF-1 gene. Fog mutant mice show aberrant expression of APAF-1 mRNA expression with greatly reduced levels of normal mRNA. fog/fog homozygous mice more readily survive into adulthood than knock-out mice completely lacking expression of ... ... ... ... ... Subscribe to continue reading! ... ...

 

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