fibro-inflammatory progenitors

abbr. FIPs. This cell type constitutes a subpopulation of perivascular mesenchymal cells found in visceral white adipose tissue (Shan B et al, 2020). Fibro-inflammatory progenitors, which express the PDGF receptor PDGFRB and Ly6C, make up approximately 60-80 % of all PDGFRB-positve cells within intra-abdominal white adipose tissue, have a fibrogenic, collagen-producing phenotype, lack adipogenic capacity, activate pro-inflammatory signalling cascades shortly after the onset of high-fat diet feeding, and regulate pro-inflammatory macrophage accumulation in white adipose tissue in a manner dependent on the activation of the Toll-like receptor TLR4. ... ... ... ...
 
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Entry last modified: January 2021