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epidermal proliferating units

[epidermal proliferating unit]

abbr. EPUs. This term refers to a population of proliferating cells in the epidermis that consists of a single stem cell surrounded by transit-amplifying cells and overlying keratinocytes undergoing squamous differentiation (Jones et al, 1995; O'Shaughnessy RF1, Christiano, 2001; Moereis et al, 1985; Mackenzie, 1997).

In human epidermis, putative stem cells plus transit-amplifying cells are identified by elevated integrin-beta-1 expression; these constitute ≈ 40 % of the basal layer so the arrangement of epidermal proliferating units in human skin is not clear (Jones et al, 1995).

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