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dorsalin-1

abbr. dsl-1. This chicken protein is a secreted member of the TGF-beta gene family. Dorsalin-1 is expressed selectively in the dorsal neural tube, and its pattern of expression appears to be restricted by early signals from the notochord. Exposure of neural plate cells to dorsalin-1 promotes the differentiation of cells with properties of neural crest cells and inhibits the induction of motor neurons by signals from the notochord and floor plate (Basler et al, 1993).

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