distal airway stem cells

abbr. DASCs. This cell type constitutes a rare population of undifferentiated lung-resident stem cells activated when the epithelial cells lining the interior of the lung are damaged by infection with influenza virus. The cells express cytokeratin Krt5 [cytokeratin-5] and a splice variant of p63 (Zuo et al, 2015), a transcription factor that regulates the epithelial differentiation program (Yang A et al, 1999), including key genes and wound repair in human airway epithelial basal cells (Warner et al, 2013). The cells proliferate and expand in response to influenza-induced lung damage and assemble into nascent alveoli at sites of interstitial lung ... ... ... ...
 
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Entry last modified: April 2021