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dendritic cell lectin

abbr. DLEC. The cDNA encoding this protein has been identified by Arce et al (2001). It encodes a type 2 integral membrane protein of 213 amino acid containing a carbohydrate recognition domain 79 % identical to the carbohydrate recognition domain of dendritic cell immunoreceptor DCIR. DLEC-beta is a splice variant. RT-PCR analysis shows DLEC expression only in peripheral blood mononuclear cells and immature dendritic cells. Northern blot analysis shows constitutive expression of DLEC in immature monocyte-derived dendritic cells that is downregulated by maturation with lipopolysaccharide but not with TNF-alpha.

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