Circular intronic RNAs |
Circulating Angiogenic Cells |
Chil3 |
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[circular RNA]
abbr. circRNAs. Circular RNAs are a subclass of non-coding single-stranded RNAs generated by a non-canonical splicing process termed back-splicing (Zhang Y et al, 2013; Qu S et al, 2017; Ebbesen et al, 2017). Back-splicing is a process in which an upstream 3′ splice site is joined to a downstream 5′ splice site through splice skipping or direct splice (in contrast to linear splicing joins a downstream 3′ splice site ito an upstream 5′ splice site). Pre-mRNA backsplicing can be controlled by the canonical splicing machinery that normaly removes introns from the primary transcripts of genes (Kulcheski et al, 2016). The majority of circular RNAs, termed exonic circRNAs (abbr.
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