cell death by neglect

also: neglect-induced death (abbr. NID); also: death by neglect. These terms have been used frequently in the context of thymocyte development and maturation that eventually yields functionally mature T-cells (Chung et al, 2002; Grebe et al, 2004; Krueger et al, 2003; Li et al, 2005; Minter and Osborne, 2003; Srivastava et al, 2007; for overview see: Klein et al, 2014). This term pertains to a default cell death pathway and usually refers to the elimination of a large number (up to 90 %) of double-positive thymocytes (see: T-cells) in the thymic cortex. Cell death by neglect is seen in double-positive thymocytes that fail to recognize wth their T-cell ... ... ... ...
 
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Entry last modified: March 2022