Cathelicidin-BF |
Cathelicidins |
Pepcan-20 |
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This antimicrobial peptide (RKCNFLCKLKEKLRTVITSHIDKVLRPQG) belongs tro the family of cathelicidins and has been isolated from skin secretions of the frog Paa yunnanensis. Cathelicidin-PY possesses strong antimicrobial activity, low hemolytic activity, low cytotoxicity against RAW 264.7 macrophage cells, and strong anti-inflammatory activity. Cathelicidin-PY exerts anti-inflammatory activity by inhibiting the production of nitric oxide and inflammatory cytokines such as TNF-alpha, IL6, and MCP-1 (CCL). Cathelicidin-PY can bind lipopolysaccharide andinhibits the activation of Toll-like receptor
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