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cancer-associated fibroblasts

[cancer-associated fibroblast, carcinoma-associated fibroblast]

Called also: tumor-associated fibroblasts (abbr. TAF). These types of fibroblasts or myofibroblasts were described originally as carcinoma-associated fibroblasts (abbr. CAF) Olumi et al (1999). These authors observed that fibroblasts associated with prostatic carcinomas (stromal fibroblasts), but not fibroblasts from normal prostate, stimulate growth, alter the histology of epithelial cells, and stimulate tumor progression of initiated non-tumorigenic epithelial cells in vivo and in vitro. Carcinoma-associated fibroblasts do not affect the growth of normal ... ... ... ... ... Subscribe to continue reading! ... ...

 

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