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base-unpairing regions

abbr. BURs. These regions are genomic DNA sequences with high unfolding potential, containing clusters of sequences (approximately 20-40 base pairs long) with a bias in G and C distribution, with one DNA strand contains only A, T and C residues (Dickinson et al, 1992; Kohwi-Shigematsu and Kohwi, 1990 Kohwi-Shigematsu et al, 2013; Bode et al, 1992). These regions within control elements maintaining independent realms of gene activity (called MARs [Matrix attachment regions] and SARs [scaffold associating regions]) are thought to occur thought the genome and are binding sites for a transcription factor termed SATB1 [special AT-rich sequence-binding protein 1] which, therefore, can engage in universal control of many different genes including some that are crucial, among other things, for ... ... ... ... ... Subscribe to continue reading! ... ...

 

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