anti-synthetase syndromes

this term refers to a rare subset of human autoimmune diseases involving the formation of antigens against a subset of aminoacyl-tRNA synthetases (Targoff, 1990; Howard et al, 2002; Hirakata et al, 1999; Mahler et al, 2014). This syndrome is characterized by multiple organ involvement, presenting with severe subtype of idiopathic inflammatory myopathies, including the development of non-erosive arthritis, myositis, Raynaud's phenomenon, mechanic's hands, interstitial lung disease, and resistance to traditional glucocorticoid therapy (for overview see also: Cojocaru M et al, 2016). Among the myositis-specific, autoantibodies against aminoacyl-tRNA synthetases represent the most common antibodies and can be detected in 25-35 % of patients. Each antibody seems to define a distinctive clinical phenotype.

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Entry last modified: January 2022