adaxial cells

This cell type in the zebrafish embryo constitutes a subset of presomitic mesodermal cells that delineates the prospective path of pioneering motor growth cones (Devoto et al, 1996; Daggett et al, 2007). Adaxial cells form a one-cell-diameter-thick pseudo-epithelium immediately adjacent to the notochord and are the progenitors of muscle pioneer cells.

Genetic ablation of adaxial cells causes profound pathfinding defects. Adaxial cells are migratory, and as growth cones approach they migrate away from the prospective axonal path to the lateral surface of the myotome. Ultimately, adaxial cells give rise to superficial slow-twitch muscle fibers and muscle pioneer cells ... ... ... ...
 
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Entry last modified: June 2021