Zika virus NS4B

[Zika virus non-structural protein 4B] abbr. ZIKV NS4B. This non-structural protein, a small transmembrane protein, is encoded in the genome of Zika virus. It has multiple functions in viral immune evasion.

Xia et al (2018) have reported that Zika virus NS4B can inhibit IFN-beta expression by reducing the phosphorylation of the interferon regulatory factor IRF3, a factor required also for the expression of interferon-stimulated gene expression.

Wu Y et al (2017) have reported that Zika virus NS4B interferes with the activity of TBK1 [TANK-binding kinase-1], which is needed to activate IRF3 and type 1 interferon ... ... ... ...
 
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Entry last modified: April 2022