Zika virus NS3

[Zika virus non-structural protein 3] abbr. ZIKV NS3. This non-structural protein is encoded in the genome of Zika virus. Together with Zika virus NS2B, Zika virus NS3 forms the Zika virus Protease.

Zika virus NS3 has been reported to play a role in viral immune evasion. Riedl W et al (2019) have reported that Zika virus NS3 blocks antiviral signaling and antiviral gene expression in response to the activation of the pattern recognition receptors RIG-I and MDA-5 by binding to and sequestering scaffold proteins 14-3-3-epsilon (for RIG-I) and 14-3-3-eta (for MDA-5 ... ... ... ...
 
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Entry last modified: April 2022