Zika virus NS2B

[Zika virus non-structural protein 2B]; abbr. ZIKV NS2B protein. This is one of several non-structural proteins, a small transmembrane protein, encoded in the genome of Zika virus. The protein, together with Zika virus NS3, forms the Zika virus Protease, which is responsible for the release of functionally non-structural proteins from the virus-encoded protein (for overview see: Li Q and Kang C, 2021).

Zika virus NS2B protein has been reported to play a role in immune evasion. The protein has been shown to antagonize IFN-beta induction by interfering with the phosphorylation of TBK1 [TANK-binding kinase-1] and preventing the phosphorylation of the interferon regulatory factor IRF3 ... ... ... ...
 
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Entry last modified: April 2022