Zika virus NS1

[Zika virus non-structural protein 1] abbr. ZIKV NS1. This non-structural protein is encoded in the genome of Zika virus. The secreted protein plays a role in immune evasion.

Zika virus NS1 blocks virus-mediated type 1 interferon signaling by targeting TBK1 [TANK-binding kinase-1] (Wu Y et al, 2017; Xia H et al).

Bos S et al (2020) have reported that Zika virus NS1 activates an inhibitory signaling cascade in plasmacytoid dendritic cells involving BDCA2 (CD303). This results in the inhibition of dendritic cell maturation and interferon type 1 responses.

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Entry last modified: April 2022