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YAVD

These amino acid residues (Tyr-Ala-Val-Asp) correspond to the caspase-1 cleavage site within IL1-beta. The synthetic tetrapeptide YAVD conjugated to 7-amino-4-trifluoromethyl coumarin (YAVD-AFC) is a fluorogenic substrate for caspase-1 which is detectable following cleavage of the substituted coumarin moiety from the peptide. The synthetic tetrapeptide YVAD conjugated to 7-amino-4-methyl coumarin (YAVD-AMC) is a fluorogenic substrate for caspase-1. YAVD-aldehyde (YAVD-CHO) is a synthetic caspase-1 inhibitor.


General note on chemical modifications: Practically all of the available caspase inhibitors, be they specific or ... ... ... ... ... Subscribe to continue reading! ... ...

 

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