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Vaccinia virus K1 protein

[Vaccinia virus K1L protein] This protein is encoded in the genome of Vaccinia virus. It is a virulence factor required for efficient replication of the virus in human cells (Drillien et al, 1981; Gillard et al, 1986). Shisler and Jin (2004) have reported a function in immunomodulation and immune evasion, showing that it inhibits the activity of the pro-inflammatory transcription factor NF-kappa-B by preventing the degradation of the endogenous inhibitor I-kappa-B-alpha. Meng et al (2009, 2012) have reported that Vaccinia virus K1L protein inhibits antiviral activities induced by type 1 interferons. The viral protein also inhibits PKR [double-stranded RNA-dependent protein kinase] activity, which is normally induced by ... ... ... ... ... Subscribe to continue reading! ... ...


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