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VPE peptide

[vascular permeability enhancing peptide] (E-kinin; SLMKRPPGFSPFRSSRI) is a kinin released from kininogens. The sequence overlaps with that of Bradykinin. It is produced by cleavage of kininogens with neutrophil elastase. The authors have suggested that a processed form, SLMKRPPGFSPFR, which has activities similar to Bradykinin and also smooth muscle contraction activity, is probably an active E-kinin moiety.

VPE peptide has blood pressure lowering activities, which are comparable to the activities of Bradykinin and completely inhibited by B2 bradykinin receptor antagonists. The peptide ... ... ... ... ... Subscribe to continue reading! ... ...

 

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