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UP-7 peptide

UP-7 peptide, PWCYVQVGLKPLVQE (Pro-Trp-Cys-Tyr-Val-Gln-Val-Gly-Leu-Lys-Pro-Leu-Val-Gln-Glu), is derived from the kringle domain of urokinase, a larger fragment of 83 amino acids that is known to inhibit angiogenesis and brain tumor growth in vivo.

UP-7 peptide most potently inhibits the proliferation and migration of endothelial cells in vitro, and also potently inhibits in vivo angiogenesis in the mouse matrigel plug assay. UP-7 peptide inhibits growth factor-induced phosphorylation of FAK and ERK1/2, suppresses the formation of stress fibers and focal adhesions, and also inhibits the attachment and spreading of endothelial cells onto immobilized ... ... ... ... ... Subscribe to continue reading! ... ...

 

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