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Tumor regressing factor

abbr. TRF (a term with multiple meanings). This biochemically uncharacterized factor of approximately 250 kDa was found in the serum of mice with S180 tumor undergoing rapid regression caused by antitumor polysaccharides. The factor causes a rapid decrease in the number of tumor cells and this is accompanied with a marked increase in neutrophils in solid tumors (Kunimoto et al, 1986, 1990).

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