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Tumor growth inhibitory factor

abbr. TGIF (a term with multiple meanings).

This biochemically uncharacterized factor of approximately 43 kDa is secreted by peripheral blood mononuclear cells activated by a preparation of streptococci (OK-432). The factor inhibits the growth of the human stomach carcinoma cell line MK-1 and is cytostatic for seven out of ten human tumor cell lines tested. A combination of suboptimal concentrations of this factor and IFN-gamma also inhibit the growth of these cells.

The activity of TGIF cannot be blocked by antibodies directed against human IFN or TNF ... ... ... ... ... Subscribe to continue reading! ... ...

 

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