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Tumor cytotoxic factor

abbr. TCF (a term with multiple meanings).

This factor is called also F-TCF (fibroblast tumor cytotoxic factor, fibroblast-derived tumor cytotoxic factor). It is detected in conditioned medium of human embryonic lung fibroblasts. The factor is cytotoxic for a number of tumor cell lines (for example, Murine sarcoma 180) and cytostatic for human KB-cells. Tumor cytotoxic factor is a potent mitogen for hepatocytes, human endothelial cells, and melanocytes.

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