thrombin-induced platelet microbicidal protein 1 |
thrombin receptor (1-41) |
HLH domain |
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abbr. TR (an abbreviation with multiple meanings), which is the same as CF2R [coagulation factor-2 receptor]. The approved gene symbol is F2R. The receptor is known also as PAR-1 [Proteinase-activated receptor 1; protease-activated receptor 1].
Cloning of the thrombin receptor (Vu et al, 1991) shows that the receptor is a member of the seven transmembrane domain receptor family of proteins. The receptor possesses a large amino-terminal extracellular extension that contains a cleavage site for thrombin 41 amino acids carboxyl to the receptor's start methionine. A peptide
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