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Thogoto virus ML protein

This protein is encoded by the elongated unspliced matrix protein M gene of the tick-transmitted orthomyxovirus Thogoto virus. Viruses deficient in ML expression are efficient interferon inducers, whereas wild-type strains expressing ML are poor interferon inducers. Expression of ML efficiently suppresses activation of the IFN-beta promoter by double-stranded RNA, suggesting that ML functions as a potent interferon antagonist by blocking transcriptional activation of IFN-alpha and IFN-beta.

For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.

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