Tc17/IFN-gamma cells |
TC22 peptide |
GILDAIKAIAKAAGamidate |
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[Tc22 cell]
In analogy to Th22 cells that produce IL22, Tc22 cells are a subpopulation of CD8(+) T-cells that produce IL22 but lack expression of IL17A and IFN-gamma. Res et al (2010) have suggested a relationship between Tc17 cells and Tc22 cells and have implicated Tc22 cells in the pathogenesis of psoriasis.
Liu et al (2011) have shown that IL21 induces the differentiation of human naive CD8(+) T-cells into Tc22 cells without the expression of IL17. The addition of TGF-beta inhibits the production of IL22 but induces the production of
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