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TU-1 antigen

This antigen is recognized by a monoclonal antibody (TU-1) directed against the Gal-alpha-1-4-Gal-beta 1-4-Glc residue of the Gb3Cer / CD77 antigen (Miyamoto et al, 1997).

TU-1 shows reactivity towards Gb3Cer and about 10-fold lower reactivity against lyso-Gb3Cer (Gal alpha 1-4Gal beta 1-4Glc beta 1-1'Sph) but not with other structurally-related glycolipids, such as LacCer (Gal beta 1-4Glc beta 1-1'Cer), Gg3Cer, Gg4Cer, Gb4Cer (GalNAc beta 1-3Gal alpha 1-4Gal beta 1-4Glc beta 1-1'Cer), galactosylparagloboside (Gal-alpha-1-3-Gal-beta-1-4-GlcNAc-beta-1-3-Gal-beta-1-4Glc-beta-1-1'Cer), sulfatide (HSO3-3Gal beta 1-1'Cer), other gangliosides (GM3, GM2, GM1a, GD1a and GT1b), or P1 antigen (Gal-alpha 1-4Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc beta 1-1'Cer) among neutral glycolipids prepared from P1 phenotype ... ... ... ... ... Subscribe to continue reading! ... ...

 

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