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TRUNDD

[TRAIL receptor with a truncated death domain] This protein is a member of the TRAIL receptor family and is expressed in multiple human tissues. The protein possesses an extracellular binding domain for TRAIL domain but lacks a functional intracellular death domain. TRUNDD does not induce cell death by apoptosis. Ectopic expression of the protein attenuates TRAIL induced apoptosis in mammalian cells (Panh et al, 1998).

Owing to its homology to other members of the TNF receptor superfamily the receptor is being referred to also as TNFRSF10D [ ... ... ... ... ... Subscribe to continue reading! ... ...

 

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