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The cDNA for TR2L (56 amino acids) was isolated from murine NIH 3T3 fibroblasts (Cao et al, 1996). In murine L929 fibrosarcoma cells expression of TR2L inhibits TNF cytotoxic response. TR2L enhances apoptosis mediated by antibodies against FAS antigen.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.
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