TPP2 |
Tpr |
reaper |
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This targeting peptide with the sequence TPAFRYS (Thr-Pro-Ala-Phe-Arg-Tyr-Ser) has been identified by phage display library screening in a search for peptides that recognize dendritic cells in order to develop an efficient dendritic cell-targeting vaccine delivery carrier (Jung et al, 2014). TP peptide-conjugated chitosan nanoparticles prepared with ovalbumin as a model vaccine demonstrate the higher targeting ability of these particles to dendritic cells in compared to chitosan nanoparticles. The TP peptide/chitosan nanoparticles also show higher targeting specificity for dendritic cells than for macrophages and myoblasts. Immunization of mice
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