TPVVPPFLQP |
TQ-1 |
vascular stem cells |
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This peptide with the sequence GPEDTSRAPENQQKTFHRRW has been identified by phage display methods (McGuire et al, 2004). It acts as a cell-targeting peptide and can be used also to mediate nanoparticle delivery to Langerhans cells. Although selected on cells in vitro, the peptide is able to direct antigens and genes to Langerhans cells in vivo. Liposomes bearing this peptide are able to deliver a transcriptionally active gene to Langerhans cells in a mouse model. A low-dose injection into mice of phage bearing this peptide yields faster and higher immune responses against phage-associated antigens than control-phage injections.
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