TLSF-beta |
TLSMLRLamide |
anthrax toxin receptor |
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[T-leukemia-derived suppressor lymphokine] This factor of approximately 88 kDa is found in the conditioned medium of various human T-leukemia cell lines.
The factor inhibits proliferation, DNA synthesis, and colony formation in a variety of malignant hematopoietic cell lines, as well as in normal myelomonocytic progenitor cells from bone marrow and peripheral blood. TLSL inhibits proliferation of normal peripheral blood T-cells in response to mitogens or alloantigens.
TLSL is cytostatic and active on cells in suspension and methylcellulose cultures. Treated target cells accumulate either in the G1 or in the S phase of the
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