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TKII-10 peptide

This synthetic peptide (RNPDGDAKPW) corresponds to amino acid Arg54-Trp63 of the kringle 2 domain of human tPA (tissue-type plasminogen activator). TKII-10 is an angiogenesis inhibitor that potently inhibits migration of endothelial cell stimulated with VEGF and tube formation but is inactive in inhibiting endothelial cell proliferation. TKII-10 also potently inhibits angiogenesis in the Chicken chorioallantoic membrane assay and the mouse Cornea pocket assay.

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