TJ6s |
TK1-2 peptide |
crustin Cm1 |
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This engineered peptide (Kwon et al, 2008) contains a cell-penetrating peptide domain (TAT cell penetrating peptide), three copies of the pro-apoptotic peptide KLAKLAKKLAKLAK separated by a caspase-3 cleavage sequence, DEVD. TK3 peptide is able to transduce into cells and then activates caspase-3, which in turn releases all three copies of the pro-apoptotic peptide by cleaving DEVD. TK3 peptide is taken up by tumor cells and induces apoptosis in vitro and in vivo. TK3 peptide also induces apoptosis and inhibits angiogenesis in
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