TIP(7-39) |
TIP-B1 |
CD59b |
||
[TNF-alpha-inducing protein] This protein is encoded by the HP0596 gene of Helicobacter pylori and is unique to Helicobacter pylori. The protein is found as a homodimer (38 kDa) in extracts and culture medium of various Helicobacter pylori strains. It significantly induces TNF-alpha gene expression and NF-kappa-B activation and can also induce cell transformation in vitro. The protein can induce expression of pro-inflammatory cytokines (TNF-alpha, IL1) in the stomach (Suganuma et al, 2005). TIP-alpha can stimulate macrophages to produce IL1-alpha and TNF-alpha (Godlewska et al, 2008).
The protein enters gastric cancer cells
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |