TIKI1 |
TIL |
Phe2-arginine-vasopressin |
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TIKI2 is an ortholog of TIKI1. The approved gene symbol is TRABD2B [TraB domain-containing protein 2B]. This gene is found in a variety of vertebrate species, including humans (Reis et al, 2014). TIKI2 is a membrane metalloprotease that cleaves Wnt proteins Wnt-3a and Wnt-5a and Xenopus laevis Wnt-8 at the amino terminus and acts as a negative regulator of Wnt signalling. Zhang R et al (2016) have reported that TIKI2 cleaves human Wnt-2b, Wnt-3, Wnt-3a, Wnt-4, Wnt-5a,
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