TIA-1-related |
Tiaf2 |
D-Arg(6),D-Trp(7,9)-N(me)Phe(8)]-substance P(6-11) |
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[TGF-beta-1 induced anti-apoptotic factor-1] TIAF-1 is a protein of 12 kDa identified as a protein the expression of which is induced by TGF-beta-1 (Chang et al, 1998). It inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adaptors TRADD, FADD, and RIP. The protein has been shown to be involved in the inhibition of I-kappa-B-alpha expression induced by TGF-beta-1 and in the suppression of TNF mediated I-kappa-B-alpha degradation.
The protein has been identified independently as MAJN, MYSPDZ [myosin-containing PDZ domain] (with a role in hematopoiesis), and
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