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TGF-beta-induced regulatory T-cells

abbr. TGF-beta-iTr, TGF-beta-iTregs. This subtype of regulatory T-cells is generated following CD4(+) CD25(-) naive T-cell activation in the presence of TGF-beta with or without retinoic acid and IL2. The cells express transcription factor Foxp3 and primarily secrete TGF-beta, and show potent suppressive activities both in vitro and in vivo (Chen et al, 2003). TGF-beta converts naive T-cells into CD4(+) CD25(+) anergic/suppressor T-cells in the periphery. These suppressor T-cells ... ... ... ... ... Subscribe to continue reading! ... ...

 

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