TCK-1 |
TCL1 |
erbA |
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This immortalized cell line has been established from the choriodecidua, transfected with a retrovirus gene coding for the SV40 large-T antigen (Lewis et al, 1996). The cells show features of trophoblasts. Conditioned medium of these cells contains M-CSF. The cells also express the M-CSF receptor, fms, suggesting the existence of an autocrine loop. Proliferation of TCL-1 cells is not affected by exogenous M-CSF but is enhanced in response to treatment with an M-CSF neutralizing antibody.
For an overview of other cell lines used in research on cytokines see:
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