TAN |
Tanapoxvirus 2L protein |
NFDEIDRSGFGFV |
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[translocation-associated notch homolog-1] This human gene locus encodes the human homolog of the Drosophila melanogaster gene Notch (Notch-1).
The human gene is encoded by a locus on chromosome 9, which is a common site for translocation with sequences from chromosome 7 in T-cell neoplasms (Ellisen et al, 1991). The mammalian gene is expressed in various human fetal tissues and adult murine tissues. Its expression is highest in lymphoid tissues and becomes disrupted by the translocation.
A human Notch homolog is expressed in CD34(+) hematopoietic
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