Staphylococcus aureus Efb
[Extracellular fibrinogen-binding protein] The gene encoding this protein of Staphylococcus aureus has been cloned by Bodén MK and Flock JI (1994), who referred to it as fib. Efb is a 19 kDa (136 amino acids) secreted binding protein for fibrinogen. Efb binds to the alpha-chain of fibrinogen and does not participate in bacterial adherence to fibrinogen (Palma et al, 1998). For a related protein see: Staphylococcus aureus ehp.
Efb has been shown to block platelet aggregation (Palma et al, 2001; Shannon and FLock, 2004) and also acts as an antiplatelet agent in vivo (Shannon et al, 2005). Efb
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