StVOrth-3 |
STX2 |
Fc-gamma R3 |
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This synthetic peptide, derived from human PEDF and corresponding to human PEDF(387-411) (DYHLNQPFIFVLRDTDTGALLFIGK), has been shown to increase the adhesion of osteosarcoma cells and to reduce the invasiveness of these cells. The peptide most significant inhibits Matrigel invasion. The peptide does not inhibit angiogenesis in a tube formation assay but suppresses VEGF expression (Ek et al, 2007).
For other proteins (or fragments thereof) with at least one additional activity that differs from the established 'classical' activity of the parent protein see also:
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