StVOrth-2 |
StVOrth-4 |
phasic neurons |
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This synthetic peptide, derived from human PEDF and corresponding to human PEDF(90-114) (SALSLGAEQRTESIIHRALYYDLIS), has been shown to exhibit anticancer peptide activity in an orthotopic model of human osteosarcoma, increasing the adhesion of osteosarcoma cells and reducing the invasiveness of these cells. The peptide markedly increases cellular adhesion to collagen-1. The peptide also induces osteoblastic differentiation. The peptide does not inhibit angiogenesis in a tube formation assay but suppresses VEGF expression (Ek et al, 2007).
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