SILPTIVSFLSKFLamide |
SIMA135 |
DPAFNSWGamide |
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This cell-penetrating peptide, AKAARQAAR, is designed after a sequence from transcription factor Sim-2 (Choi JM et al, 2012).
Sim-2 cell-permeable peptide conjugated to beta-galactosidase or enhanced green fluorescent protein is delivered efficiently into cells in vitro and in vivo. A cell permeable form of the NFAT inhibitory peptide VIVIT has been shown to enter the cells and to inhibit human CD4 or CD8 T-cell activation through transcriptional suppression of NF-AT [nuclear factor for activated T-cells] activity and inhibition of IL2. Intranasal administration of this fusion peptide in an ovalbumin-induced
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