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Sheeppox virus SPPV14

This protein is encoded by sheeppox virus. SPPV14 has been shown to inhibit cell death by apoptosis induced by multiple agents. SPPV14 appears to act at the mitochondrial checkpoint and not at the level of caspases, since it potently inhibits cytochrome C release. SPPV14 appears to be equipotent to Myxoma virus M11L in apoptosis inhibition and can compensate for the loss of anti-apoptotic F1L in vaccinia virus and acts to directly counter the cell death mediators BAX and BAK. SPPV14 also engages a unique subset of the death-promoting BH3-only ligands, including BIM, PUMA, BCL2 modifying factor, and Hrk.

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