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Sesquin

This antifungal peptide with an N-terminal sequence highly homologous to defensin has been isolated from ground beans (Vigna sesquipedalis cv. 'Ground Bean') (Wong and Ng, 2005). The peptide has antifungal activity against Botrytis cinerea, Fusarium oxysporum and Mycosphaerella arachidicola. It is antibacterial for Escherichia coli B, Proteus vulgaris, Mycobacterium phlei and Bacillus megaterium. The peptide shows antiproliferative activity towards breast cancer (MCF-7) cells and M1 mouse leukemia cells. It also exhibits some inhibitory activity towards human immunodeficiency virus-type 1 reverse transcriptase.

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