Scolopendin |
Scolopendin 2 |
GATS |
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Scolopendin 1, MDSFQKIEKIGEGTYGVVYKAKDKVSGRLVALKKIRLENESEGVPSTAamide, has been isolated from adult centipedes, Scolopendra subspinipes mutilans (Choi et al, 2014). The peptide has antimicrobial activity and is not hemolytic for human erythrocytes. It causes the production of reactive oxygen species in Candida albicans and subsequent cell death by apoptosis. The accumulation of reactive oxygen species triggers mitochondrial depolarization and the release of cytochrome C from mitochondria, which then activates intracellular caspase.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.
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