SV40-induced 24P3 protein |
SV40 VP2 protein |
DN3 cells |
||
This protein is encoded by Simian virus SV40. T antigen is a known inactovator of tumor suppressor proteins and has been used extensively to study the mechanisms of cellular growth control and transformation. Expression of this antigen in transformed cells has been used to generate immortalized cell lines.
T antigen has been shown to blocks cell death by apoptosis. It prevents apoptosis independently of the activation of the p53 tumor suppressor protein (Conzen et al, 1997). The mechanism involves suppression of caspase-1 activity (Jung and Yuan, 1997). The protein protects against apoptosis elicited in a neural stem cell line (SFME cells
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |
| SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials |
| # | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
|
Created, developed, and maintained by Dr H Ibelgaufts
|
U L T R A P O S S E N E M O O B L I G A T U R