STAP |
Staphylocoagulase |
F2-alpha receptor regulatory protein |
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[STAP cell]
STAP (a term with multiple meanings) is the acronym for stimulus-triggered acquisition of pluripotency. STAP cells are mammalian somatic cells that have acquired pluripotent characters after simple short-term exposure to strong external stimuli such as a transient low-pH. This technique does not require nuclear transfer or genetic manipulation involving the introduction of transcription factors (see also: iPS cells [induced pluripotent stem cells]). STAP cells are derived from purified lymphocytes by reprogramming rather than selection (Obokata et al, 2014). STAP cells show a substantial decrease in DNA methylation in the regulatory regions of pluripotency
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